Genetic susceptibility to non-insulin dependent diabetes

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Genetic susceptibility to non-insulin dependent diabetes mellitus and glucose intolerance are located in HLA region.

OBJECTIVES To test the hypothesis that the genetic susceptibility to non-insulin dependent diabetes mellitus is the same as that to insulin dependent disease and to see whether glucose intolerance is associated with specific HLA haplotypes. DESIGN Population based study of men in 1989 first tested for glucose tolerance in 1984. HLA haplotypes, including HLA-A, C, B, DR, and DQ, were defined s...

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Dental damages in non-insulin dependent diabetes patients

Introduction: Changes in saliva and its biochemical content in diabetic patients can effect on supportive dental tissues and cause dental damage. Low carbohydrate diets, and good control of disease can reduce dental damage in diabetics. The aim of this study was to compare dental damage in patients with non-insulin dependent diabetes mellitus (NIDDM) patients and healthy individuals. Methods: ...

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Genetic Susceptibility to Transient and Permanent Neonatal Diabetes Mellitus

Neonatal diabetes mellitus (NDM) is a rare kind of diabetes characterized by hyperglycemia and low levels of insulin. Clinically, it is categorized into two main types: transient NDM (TNDM) and permanent NDM (PNDM). These types are diagnosed based on duration of insulin dependence early in the disease. In TNDM, diabetes begins in the first few weeks of life with remission in a few months. Howev...

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Non-insulin-dependent diabetes mellitus.

Non-insulin-dependent diabetes mellitus (NIDDM) occurs predominantly after the age of 50 years but is not easy to distinguish from late onset insulin-dependent diabetes. It is likely that misclassification is rare in a Caucasian population. Whilst NIDDM is widely believed to be genetically determined, recent epidemiological observations have consistently revealed statistical associations betwee...

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Maternally transmitted susceptibility to non-insulin-dependent diabetes mellitus and left ventricular hypertrophy.

OBJECTIVES We studied the association of diabetes transmission with left ventricular hypertrophy (LVH) in patients with non-insulin-dependent diabetes mellitus (NIDDM). BACKGROUND It is suggested that NIDDM has a strong genetic basis and that maternally transmitted NIDDM is associated with mitochondrial deoxyribonucleic acid (DNA) mutations. However, genetic factors for LVH in NIDDM are unkno...

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ژورنال

عنوان ژورنال: BMJ

سال: 1994

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.308.6927.534a